Which tricyclic antidepressant is commonly used to treat childhood enuresis?

Imipramine is recognized as the tricyclic antidepressant most commonly used to treat childhood enuresis, or bedwetting. Its efficacy in this context is attributed to its ability to increase bladder capacity and improve nighttime arousal from sleep. It acts as a serotonin-norepinephrine reuptake inhibitor, which contributes to its mood stabilizing effects.

In children suffering from enuresis, imipramine can help reduce the frequency of episodes, as it has a calming effect and may assist children in recognizing the need to wake up during the night to use the bathroom. Clinicians often prescribe imipramine after other behavioral interventions have been attempted without success, making it a second-line treatment for persistent cases of enuresis.

While other tricyclic antidepressants like desipramine and clomipramine have similar properties, their primary indications differ from that of imipramine, which has evidenced efficacy in specifically addressing the symptoms associated with childhood enuresis. Understanding these nuances about each medication's applicability and mechanisms can guide healthcare providers in selecting the best treatment for their pediatric patients.