Which risk factor is most often associated with the development of meralgia paresthetica?

Meralgia paresthetica is characterized by numbness, tingling, or burning pain in the outer thigh, resulting from compression of the lateral femoral cutaneous nerve as it passes under the inguinal ligament. Obesity is a significant risk factor for this condition, largely due to the increased abdominal girth and pressure it places on the nerves in the pelvic region. The excess weight can contribute to a mechanical environment that predisposes individuals to nerve compression, particularly where the nerve passes through narrow anatomical spaces.

Heavy alcohol use does not have a direct association with the condition and tends to be more closely linked to peripheral neuropathy in other contexts. Frequent physical activity is generally beneficial and tends to promote nerve health, while previous knee injuries may not have a straightforward connection to meralgia paresthetica, as the condition primarily involves the lateral femoral cutaneous nerve rather than the knee. Thus, the link between obesity and the development of meralgia paresthetica stands out as the most relevant risk factor.