Which psychotropic medication class is less likely to be associated with extrapyramidal symptoms?

The class of psychotropic medications that is less likely to be associated with extrapyramidal symptoms is atypical antipsychotics. Atypical antipsychotics, such as clozapine, risperidone, and quetiapine, have a different mechanism of action compared to typical antipsychotics. They primarily target serotonin receptors in addition to dopamine receptors, which is thought to contribute to a lower incidence of extrapyramidal side effects.

Extrapyramidal symptoms, including symptoms such as tremors, rigidity, and bradykinesia, are more commonly associated with typical antipsychotics (first-generation antipsychotics) due to their strong antagonism at dopamine D2 receptors in the brain. These symptoms arise from the blockade of dopamine pathways that are involved in motor control.

SSRIs (selective serotonin reuptake inhibitors) and benzodiazepines also do not typically cause extrapyramidal symptoms. SSRIs are primarily used to treat depression and anxiety through the modulation of serotonin levels, whereas benzodiazepines are central nervous system depressants used for their anxiolytic, sedative, and muscle relaxant properties. While these medications have their own side effect profiles, extrapyramidal symptoms are not