Which medication is a serotonin and norepinephrine reuptake inhibitor with indications for neuropathic pain?

Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) that is specifically indicated not only for the treatment of major depressive disorder and generalized anxiety disorder but also for chronic pain conditions, including neuropathic pain. It works by increasing the levels of serotonin and norepinephrine in the brain, which can help to alleviate pain perception and improve mood. This dual mechanism is particularly beneficial in managing neuropathic pain, as it addresses both the emotional and physical components of the condition.

The other medications listed have different primary uses and mechanisms. Mirtazapine is primarily an antidepressant that works as a noradrenergic and specific serotonergic antidepressant, and while it can be used for certain anxiety and depressive disorders, it is not typically prescribed for neuropathic pain. Quetiapine is an atypical antipsychotic mainly used for managing conditions like schizophrenia and bipolar disorder; it lacks the specific indication for neuropathic pain. Nefazodone, while it does have some serotonin reuptake inhibition properties, is not primarily used for neuropathic pain and has been largely supplanted by other agents due to safety concerns.

In summary, duloxetine's specific role as a SNRI that effectively