In a cocaine overdose, which brain region is primarily responsible for the sensation of reward?

The sensation of reward in the brain is primarily associated with the nucleus accumbens. This region is a critical component of the brain's reward circuitry, which is heavily influenced by dopaminergic pathways. Cocaine increases the levels of dopamine in this area by inhibiting the reuptake of dopamine, thereby enhancing the feeling of euphoria and reinforcing drug-seeking behavior.

The nucleus accumbens integrates information from various brain regions and is particularly responsive to natural rewards, such as food and social interactions, as well as drugs of abuse like cocaine. This is why it plays a central role in the reward pathway—the activation of the nucleus accumbens motivates individuals to seek out rewarding experiences.

In contrast, the neocortex is involved in higher-order cognitive functions and decision-making, while the locus ceruleus is primarily associated with arousal and stress responses. The raphe nuclei are involved in regulating mood and arousal through serotonin release. While all these regions contribute to the overall experience of reward and motivation, the nucleus accumbens is specifically identified as the primary region responsible for the sensation of reward in the context of a cocaine overdose.