A toddler presents with seizures and a facial port-wine stain. This condition is indicative of?

The presence of a facial port-wine stain in conjunction with seizures suggests Sturge-Weber syndrome. This neurocutaneous condition is characterized by a facial angioma, particularly in the distribution of the trigeminal nerve, and is associated with neurological complications such as seizures and developmental delays.

In Sturge-Weber syndrome, the port-wine stain is typically found on the face and can be accompanied by leptomeningeal angiomatosis, which can lead to cortical calcifications and subsequent seizures. The seizures in these patients often begin in early childhood and may be resistant to treatment, highlighting the importance of identifying this condition for proper management.

Other conditions listed, while they may also present with various neurological symptoms, do not specifically correlate with the combination of a facial port-wine stain and seizures. For example, tuberous sclerosis often presents with skin findings like facial angiofibromas and other tumors, Fabry's disease is characterized by systemic involvement and does not typically include port-wine stains or seizures, and ataxia-telangiectasia presents with neurological deficits and immunodeficiency without the specific cutaneous manifestations seen in Sturge-Weber syndrome. Thus, the specific combination of symptoms in this scenario strongly points to Sturge-Weber