American Board of Psychiatry and Neurology (ABPN) Practice Exam

Question: 1 / 1275

A patient presents with confusion, myoclonus, and GI symptoms. Which condition does this most likely indicate?

Neuroleptic malignant syndrome

Serotonin syndrome

The presence of confusion, myoclonus, and gastrointestinal symptoms points towards serotonin syndrome, a potentially life-threatening condition that occurs due to excessive serotonergic activity in the central nervous system. This syndrome often arises following the use of serotonergic medications, and the symptoms develop rapidly after exposure to these drugs.

Confusion indicates altered mental status, commonly seen in serotonin syndrome, as the elevated levels of serotonin affect cognitive functions. Myoclonus refers to sudden, involuntary muscle jerks, which frequently appear in this condition due to the overstimulation of the central nervous system. Gastrointestinal symptoms, such as nausea, vomiting, and diarrhea, are also characteristic features, resulting from the effects of increased serotonin in the gut.

Understanding these symptoms in the context of serotonin syndrome allows for timely intervention and management, as recognizing this condition can prevent severe complications. Other conditions, while they may show some overlapping features, do not present with this specific triad of symptoms.

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Dementia with Lewy bodies

Acute psychosis

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